Amyloid

Amyloid Beta Protein

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen within the hippocampus, neocortex, and amygdala of sufferers with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) kinds cation based mostly ion channels.

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Basic description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current within the vascular amyloid deposits. Aβ40 contains of C-terminal membrane insertion area. It exhibits structural transition from random coil to a α-helical construction in a water-micelle medium.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • within the temperature based mostly conformational research utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) research
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of sufferers with head trauma
  • as a element of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
amyloid
amyloid

Reconstitution

For maximal organic exercise, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Different Notes

Lyophilized from 0.1% TFA in H2O

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology within the human mind and the diploma of scientific dementia. Current advances in our understanding of the event of amyloid pathology have helped remedy this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in numerous swimming pools, could also be extra carefully associated to illness state. The composition of those swimming pools of Aβ displays completely different populations of amyloid deposits, and has particular correlates with the scientific standing of the affected person. Imaging applied sciences, together with new amyloid imaging brokers based mostly on the chemical construction of histologic dyes, at the moment are making it doable to trace amyloid pathology together with illness development within the residing affected person. Curiously, these approaches point out that the Aβ deposited in AD is completely different from that present in animal fashions. Basically, deposited Aβ is extra simply cleared from the mind in animal fashions, and doesn’t present the identical bodily and biochemical traits because the amyloid present in AD. This raises necessary points concerning the event and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Amyloid Beta Protein

SPR-485H 1 mg
EUR 435
Description: Human Synthetic Amyloid Beta Peptide 1-42 (HFIP treated)

Amyloid Beta Protein

SPR-487B 100 µg
EUR 382
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-487C 100 µg x2
EUR 611
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-487E 100 µg x5
EUR 1240
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-488B 100 µg
EUR 617
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488C 100 µg x2
EUR 988
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488E 100 µg x5
EUR 1998
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-492B 100 µg
EUR 432

Amyloid Beta Protein

SPR-492C 100 µg x2
EUR 691
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-492E 100 µg x5
EUR 1405
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid beta A4 protein

AP79877 1mg
EUR 2640

Amyloid beta A4 protein

AP80103 1mg
EUR 2640

Amyloid beta A4 protein

AP80119 1mg
EUR 2640

Amyloid beta A4 protein

AP80183 1mg
EUR 2640

Amyloid beta A4 protein

AP80191 1mg
EUR 2640

Amyloid beta A4 protein

AP78722 1mg
EUR 2640

Amyloid beta Protein (20-29)

20-abx266170
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  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (33-42)

20-abx266417
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  • 10 mg
  • 25 mg
  • 5 mg
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