Amyloid

Amyloid Beta Protein

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen within the hippocampus, neocortex, and amygdala of sufferers with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) kinds cation based mostly ion channels.

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Basic description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current within the vascular amyloid deposits. Aβ40 contains of C-terminal membrane insertion area. It exhibits structural transition from random coil to a α-helical construction in a water-micelle medium.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • within the temperature based mostly conformational research utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) research
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of sufferers with head trauma
  • as a element of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
amyloid
amyloid

Reconstitution

For maximal organic exercise, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Different Notes

Lyophilized from 0.1% TFA in H2O

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology within the human mind and the diploma of scientific dementia. Current advances in our understanding of the event of amyloid pathology have helped remedy this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in numerous swimming pools, could also be extra carefully associated to illness state. The composition of those swimming pools of Aβ displays completely different populations of amyloid deposits, and has particular correlates with the scientific standing of the affected person. Imaging applied sciences, together with new amyloid imaging brokers based mostly on the chemical construction of histologic dyes, at the moment are making it doable to trace amyloid pathology together with illness development within the residing affected person. Curiously, these approaches point out that the Aβ deposited in AD is completely different from that present in animal fashions. Basically, deposited Aβ is extra simply cleared from the mind in animal fashions, and doesn’t present the identical bodily and biochemical traits because the amyloid present in AD. This raises necessary points concerning the event and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Amyloid beta Protein (33-42)

20-abx266417
  • EUR 644.40
  • EUR 1078.80
  • EUR 460.80
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta 1-42 Protein

abx060277-100ug 100 ug
EUR 910.8

beta Amyloid 40 protein

30R-3013 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

[Lys15]-Amyloid beta Protein (15-21)

20-abx265888
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (25-35) amide

20-abx266281
  • EUR 594.00
  • EUR 978.00
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Amyloid Beta (A4) Precursor Protein

PR27172 10 ug
EUR 381.6

Amyloid Beta A4 Protein (APP) Antibody

20-abx137437
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Amyloid Beta A4 Protein (APP) Antibody

20-abx210155
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Amyloid Beta A4 Protein (APP) Antibody

abx230512-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx230513-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx224105-100ug 100 ug
EUR 493.2

Amyloid Beta A4 Protein (APP) Antibody

abx146535-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx146606-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx412477-01mg 0.1 mg
EUR 644.4

Amyloid Beta A4 Protein (APP) Antibody

abx412509-01ml 0.1 ml
EUR 844.8

Amyloid Beta A4 Protein (APP) Antibody

abx412510-01ml 0.1 ml
EUR 844.8

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